# Molecular docking analysis of phytochemicals from Soothaga Thadai Kudineer with cyp-17α-hydroxylase enzyme

## TL;DR

This study explores how certain plant compounds from Soothaga Thadai Kudineer may inhibit an enzyme linked to PCOS symptoms.

## Contribution

The study identifies specific phytochemicals with strong binding potential to the CYP17 enzyme, suggesting their role in PCOS management.

## Key findings

- Gingerenone A, chlorogenic acid, and piperine show strong binding affinities to CYP17.
- These phytochemicals may act as potential inhibitors of the CYP17 enzyme.
- The findings suggest a scientific basis for using Soothaga Thadai Kudineer in PCOS treatment.

## Abstract

Polycystic ovarian syndrome (PCOS) affects 9.2% of women of reproductive age and has doubled in prevalence, rising from 6 million
cases in 1990 to 12.13 million in 2019. PCOS is characterized by symptoms like irregular periods, acne, hirsutism, male-pattern baldness,
weight gain, mood swings and infertility. PCOS is primarily associated with elevated androgen levels. The use of Indian Soothaga
Thadai Kudineer for managing PCOS is well documented. Therefore, it is of interest to report the Molecular docking
analysis of phytochemicals from Indian Soothaga Thadai Kudineer with cyp-17α-hydroxylase enzyme (CYP17). Analysis
shows that phytochemicals such as gingerenone A, chlorogenic acid and piperine present in Soothaga Thadai Kudineer
exhibit strong binding affinities to the enzyme suggesting their potential as CYP17 inhibitors for further validation and consideration.