Pathological predictors for curettage and cementation outcome in proximal tibial giant cell tumors

TL;DR

This study identifies tumor grade and cortical involvement as key predictors of recurrence in proximal tibial giant cell tumors treated with curettage and cementation.

Contribution

The study introduces tumor grade and cortical involvement as significant pathological predictors for recurrence in proximal tibial GCT.

Findings

Tumor grade and cortical involvement were identified as main predictors of recurrence.

Most tumors were Grade 2 with 62.5% cortical involvement.

Acceptable functional outcomes were observed with an average MSTS score of 27.2.

Abstract

Proximal tibia giant cell tumors (GCT) are aggressive with high-recurrence rate, function-affecting and benign neoplasms. Therefore,
it is of interest to report the pathological predictors for curettage and cementation outcome in proximal tibial giant cell tumors.
Hence, 32 patients treated with curettage, poly-methyl-methacrylate (PMMA) cementation and locking plate fixation between 2018 and 2022
was included in this study. The average age of patients was 28.1 ± 6.9 years and most tumors were Grade 2 (campanacci grade) with
62.5% cortical involvement. The average musculo-skeletal tumor society (MSTS) score was 27.2 ± 4.2 with acceptable function.
Thus, tumor grade and cortical involvement were the main predictors of recurrence, reflecting the need for targeted treatment.

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