Novel endoscopic gastric purse-string suture device for weight management in a porcine model (with video)

TL;DR

A new endoscopic device was tested in pigs to help manage weight by reducing stomach volume and improving metabolic outcomes.

Contribution

A novel endoscopic gastric purse-string suture device was developed and evaluated for weight management.

Findings

The device reduced gastric fundus volume effectively in a porcine model.

Histological and metabolic outcomes indicated the procedure's viability for metabolic control.

Abstract

Obesity is a global health issue. Traditional treatment modalities such as lifestyle modifications, pharmacological interventions, and bariatric surgery often present various limitations. Recently, endoscopic bariatric and metabolic therapies (EBMTs) have emerged as promising minimally invasive approaches for weight management. These therapies reduce gastric volume and energy intake, prolong gastric emptying, and regulate hormones associated with satiety. This study evaluated endoscopic gastric purse-string suturing (EGPSS), a novel endoscopic procedure designed to reduce gastric fundus volume while minimizing associated risks. We assessed its feasibility and efficacy in a porcine model in terms of histological, physiological, and metabolic outcomes. The results suggest that EGPSS offers a viable option for metabolic control.

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