# Transcatheter tricuspid valve replacement: will it prevail?

**Authors:** Xiling Zhang, Nina Sophie Pommert, David Meier, Stephanie L. Sellers, Hatim Seoudy, Oliver J. Müller, Derk Frank, Tim Attmann, Rouven Berndt, Gregor Warnecke, Thomas Puehler, Georg Lutter

PMC · DOI: 10.3389/fcvm.2025.1562658 · Frontiers in Cardiovascular Medicine · 2025-04-16

## TL;DR

This review discusses the potential of transcatheter tricuspid valve replacement as a promising treatment for severe tricuspid regurgitation.

## Contribution

The paper provides an updated review of TTVR advancements, clinical findings, and challenges in managing severe TR.

## Key findings

- TTVR is emerging as a promising alternative for high-risk patients unsuitable for conventional surgery.
- Procedural outcomes and patient selection criteria are critical for successful TTVR implementation.
- TTVR has the potential to transform the treatment landscape for severe tricuspid regurgitation.

## Abstract

Severe tricuspid regurgitation (TR) is a prevalent and challenging condition associated with poor survival outcomes and significant morbidity. Medical therapy alone often fails to provide adequate symptom relief, and stand-alone surgical intervention is linked to high mortality rates, making it a less favorable option unless combined with left-sided valve surgery. The advent of transcatheter tricuspid interventions has provided new therapeutic possibilities, particularly for high-risk patients who are ineligible for conventional surgery. However, many patients are still unsuited for transcatheter tricuspid repair or have only limited benefits from such procedures. In this context, Transcatheter tricuspid valve replacement (TTVR) has rapidly emerged as a promising alternative, offering the potential for more effective treatment outcomes. This review explores the latest advancements in TTVR devices, highlights key clinical findings, and discusses the challenges and limitations of this evolving strategy. Additionally, we address patient selection criteria, procedural outcomes, and future directions in the field, emphasizing the potential of TTVR to transform the management of severe TR.

## Full-text entities

- **Diseases:** TR (MESH:D014262)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12040945/full.md

## References

76 references — full list in the complete paper: https://tomesphere.com/paper/PMC12040945/full.md

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Source: https://tomesphere.com/paper/PMC12040945