# Case Report: Two cases of atypical neurofibroma neoplasm of uncertain biological potential in the nasal cavity and a literature review

## TL;DR

This case report describes two rare nasal tumors called atypical neurofibroma neoplasm of uncertain biological potential and their successful treatment with surgery and follow-up.

## Contribution

The study presents two new clinical cases of a rare nasal tumor and contributes to the limited literature on its diagnosis and treatment.

## Key findings

- Both patients underwent surgery and showed satisfactory recovery with no recurrence or metastasis.
- One patient received postoperative radiotherapy as part of the treatment.
- The study supports surgical intervention as an effective treatment for nasal ANNUBP.

## Abstract

This study aims to investigate the clinical diagnosis, treatment processes, and pathological characteristics of two cases of atypical neurofibroma neoplasm of uncertain biological potential (ANNUBP) located in the nasal cavity.

We retrospectively analyzed the medical history, imaging studies, pathological results, and follow-up data of two patients diagnosed with nasal ANNUBP who were admitted to Qingdao University Hospital between June and October 2023. A review of relevant literature was conducted to summarize their clinical characteristics, diagnosis, treatment, and prognosis.

Both patients underwent surgical treatment, with one receiving postoperative radiotherapy. Follow-up evaluations indicated that both patients experienced satisfactory recovery, with no signs of local recurrence or distant metastasis.

ANNUBP is a recently recognized and rare subtype of neurogenic tumor. Surgical intervention is regarded as an effective treatment method. This study adhered to established treatment principles for nasal tumors and achieved satisfactory outcomes through surgical intervention and diligent postoperative follow-up.