# Spatial and Temporal Distribution of Pediatric Cancers in Southern Ghana: A Retrospective Observational Study

## TL;DR

This study examines where and when pediatric cancers occurred in southern Ghana to identify clusters and potential environmental factors.

## Contribution

The study provides a spatial and temporal analysis of pediatric cancer cases in southern Ghana using statistical tools to detect clusters.

## Key findings

- Pediatric cancer cases increased over five years in southern Ghana.
- Males had a 24% higher incidence rate of pediatric cancer compared to females.
- Three significant cancer clusters were identified in the Bono East and Ashanti Regions.

## Abstract

More than 80% of children living with cancer reside in developing countries like Ghana, with over 1000 new cases projected each year. Spatial analysis of pediatric cancers provides insights into possible environmental risk factors, potential genetic associations, and the identification of clusters or hotspots, which can guide further investigation into causal factors and inform population‐level interventions.

This retrospective observational study aimed to investigate the spatial distribution dynamics of pediatric cancer cases diagnosed at the Komfo Anokye Teaching Hospital, Ghana.

Poisson regression and spatial statistical tools, including Kernel Density Estimation (KDE) and Kulldorff's spatial scan statistics, were used to analyze 652 pediatric cancer cases recorded from 2018 to 2022 in Southern Ghana.

The results revealed increasing pediatric cancer cases over the 5 years. Burkitt Lymphoma, Leukemia, Nephroblastoma, Other Non‐Hodgkins Lymphoma, and Retinoblastoma had higher incidence among children, with males having a 24% higher incidence rate compared to females (Incident Rate Ratios [IRR] estimated at 1.24 at p < 0.01, 95% confidence interval [CI): 1.06, 1.45). Further, the KDE plot consistently revealed a high density of reported cases in the central part of the study area, with a noticeable directional diffusion of pediatric cancer cases toward the northwest from 2018 to 2022. Three significant clusters of relative risk between 1.65 and 2.17, p < 0.01, were identified, covering parts of the Bono East and Ashanti Regions of Ghana.

Clustering cancer cases could suggest a possible environmental influence on the occurrence of the disease. Although this study offers relevant baseline information, comprehensive epidemiological investigations are necessary to establish specific environmental risk factors and potential gene‐environment interactions contributing to this pediatric cancer clustering.