# Retro-orbital Metastasis in Chromophobe Renal Cell Carcinoma: A Case Report and Review

## TL;DR

A rare case of chromophobe renal cell carcinoma spreading to the eye area is reported, showing some treatment success but ultimately aggressive disease progression.

## Contribution

This case report highlights retro-orbital metastasis in ChRCC and the potential benefit of palliative radiotherapy.

## Key findings

- The patient showed rapid improvement in eye symptoms after radiotherapy.
- ChRCC exhibited aggressive progression despite localized treatment success.
- Retro-orbital metastasis is a rare presentation of chromophobe renal cell carcinoma.

## Abstract

Chromophobe renal cell carcinoma (ChRCC) is a rare subtype of renal cell carcinoma (RCC). We present a case of a 61-year-old male with ChRCC who exhibited unusual metastasis to the retro-orbital area, a site rarely affected by RCC. The patient experienced diplopia and proptosis, prompting treatment with sunitinib and palliative radiotherapy. Remarkably, rapid improvement in ocular symptoms was observed following radiotherapy. Despite this localized response, the patient’s overall condition deteriorated, highlighting the aggressive nature of ChRCC. This case underscores the importance of considering ChRCC in metastatic presentations and the potential efficacy of local palliative interventions.