# Synthesis of 2-acetylnoviosamine derivatives by hydrogenolytic cleavage of a spirocyclopropane

## TL;DR

This paper describes a new method to synthesize a rare sugar derivative using a cyclopropanation and hydrogenolytic cleavage strategy.

## Contribution

The novel approach introduces a gem-dimethyl group in the synthesis of 2-acetamido noviose derivatives.

## Key findings

- A 2-acetamido derivative of noviose was successfully synthesized.
- The method uses cyclopropanation and hydrogenolytic cleavage to introduce the gem-dimethyl feature.
- The strategy allows synthesis of both l- and d-noviose derivatives.

## Abstract

The preparation of a 2-acetamido derivative of the rare 5,5-gem-dimethyl-deoxy carbohydrate noviose is reported in this study. The synthesis starts from readily available N-acetyl-d-mannosamine and tackles the introduction of the gem-dimethyl structural feature via a cyclopropanation and hydrogenolytic cleavage strategy, which can enable the synthesis of 2-amino noviose derivatives of both l- and d-noviose.

The preparation of a 2-acetamido derivative of the rare 5,5-gem-dimethyl-deoxy carbohydrate noviose is reported in this study.