# Best evidence summary for preventing and preventing epidermal growth factor receptor inhibitors induced paronychia in cancer patients

## TL;DR

This paper summarizes the best evidence for preventing and managing paronychia caused by epidermal growth factor receptor inhibitors in cancer patients.

## Contribution

It provides a structured summary of 12 evidence-based recommendations from 20 sources for clinical practice.

## Key findings

- 12 evidence-based recommendations were synthesized from 20 articles, including guidelines and expert consensus.
- Recommendations cover risk assessment, training, prevention, and treatment of paronychia.
- The study emphasizes individualized application of evidence in clinical practice.

## Abstract

To evaluate and summarize the best evidence for preventing and managing epidermal growth factor receptor inhibitors induced paronychia in cancer patients. It aims to provide a reference for medical staff.

We systematically searched for evidence on paronychia symptoms in 14 databases such as Cnki、Wanfang, 7 guide websites such as GIN and NZGG, and 8 professional websites such as UICC and ACS from database establishment to August 2024. Two researchers evaluated the quality of the literature and extracted the data.

A total of 20 articles were included in this study, including 5 clinical decisions、5 guidelines、3 evidence summaries 、3 recommended practices, and 4 experts consensuses. Finally, 12 pieces of evidence were summarized from 4 aspects, including risk factor assessment, professional healthcare training, preventive measures, and therapeutic measures.

Our research summarizes the best evidence for preventing and managing epidermal growth factor receptor inhibitors induced by paronychia in cancer patients. In the actual clinical application, it is necessary to fully consider the clinical situation, combine the judgment of professionals and patients’ wishes, follow the principle of individualization, analyze the obstacles and facilitating factors of the application of evidence, and apply the evidence to the clinical practice prudently.