# Hyalinizing pancreatic adenocarcinoma in a cat

## TL;DR

A cat was diagnosed with a rare type of pancreatic cancer called hyalinizing adenocarcinoma, which showed a slower progression over 28 months.

## Contribution

This is the first reported case of hyalinizing pancreatic adenocarcinoma in a cat, suggesting a potentially less aggressive behavior.

## Key findings

- The cat had non-resectable pancreatic masses with histologic features of hyalinizing exocrine pancreatic adenocarcinoma.
- The tumor showed progressive enlargement but no chemotherapy was pursued, and the cat remained alive 28 months later.
- The case suggests that this subtype may behave less aggressively in cats, similar to observations in dogs.

## Abstract

A 6-year-old female spayed domestic shorthair cat was presented for abdominal distension and weight loss. Abdominal radiographs and ultrasound revealed two cranial abdominal masses and another mass adjacent to the jejunum. Cytologic features of the cranial abdominal masses were consistent with exocrine pancreatic tissue. Four months later, a repeat abdominal ultrasound revealed progressive enlargement of the abdominal masses and medial iliac lymphadenopathy. On exploratory laparotomy, two abdominal masses were associated with the pancreas and incorporated large blood vessels supplying the liver, pancreas and spleen. The masses were non-resectable and incisional biopsies were obtained. The histologic features were diagnostic for a hyalinizing subtype of exocrine pancreatic adenocarcinoma. Chemotherapy was not pursued. Over 28 months after the initial detection of abdominal masses, the cat was still alive and reportedly doing well.

To the authors’ knowledge, this is the first report of a hyalinizing subtype of pancreatic adenocarcinoma in a cat. This subtype is considered to behave less aggressively in dogs, and this case may support that a similar, more indolent behavior may be seen in cats.