Primary Mesenteric Well-Differentiated Inflammatory Liposarcoma With Mucosal Extension: A Lesion With High Risk for Misdiagnosis

TL;DR

A rare case of a primary mesenteric liposarcoma with mucosal extension is presented, highlighting the risk of misdiagnosis and the need for careful analysis.

Contribution

The paper reports a rare case of primary mesenteric well-differentiated inflammatory liposarcoma with mucosal extension.

Findings

Primary mesenteric well-differentiated inflammatory liposarcomas are exceedingly rare.

Such lesions are at high risk for misdiagnosis, especially when first seen in endoscopic biopsies.

Accurate diagnosis requires histopathology, immunohistochemistry, and MDM2 amplification testing.

Abstract

Well-differentiated liposarcomas are common retroperitoneal lesions, but exceedingly rare when primary to the small bowel mesentery, with only a handful of cases reported in the literature. Presented is a patient with a primary mesenteric well-differentiated inflammatory liposarcoma with mucosal extension at high risk for misdiagnosis. A broad differential diagnosis with careful histopathologic observation, ancillary immunohistochemical studies, and fluorescent in situ hybridization for MDM2 amplification are key to make a correct diagnosis. This is especially true if such a lesion was first noted in the lamina propria on histopathology from an endoscopic mucosal biopsy.

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