Plasma cell leukemia: new diagnostic and therapeutic perspectives (about five cases)
Assya Khermach, Meryem Sabia, Nisma Douzi, Abdelilah Berhili, Mounia Slaoui, Mohammed Bensalah, Rachid Seddik
TL;DR
This paper discusses five cases of plasma cell leukemia and highlights new diagnostic and treatment approaches for this rare blood disorder.
Contribution
The study emphasizes the role of hematologic cytology in diagnosis and explores innovative therapies for plasma cell leukemia.
Findings
Five cases of plasma cell leukemia were collected and analyzed.
The importance of detecting ≥5% circulating plasma cells for diagnosis is highlighted.
Innovative therapeutic strategies are discussed for this rare condition.
Abstract
La leucémie à plasmocytes (LP) est un désordre lymphoprolifératif rare, caractérisée par une prolifération clonale des plasmocytes dans la moelle osseuse et le sang périphérique. En 2021, l'International Myeloma Working Group (IMWG) a redéfini la LP par la présence de 5% ou plus de plasmocytes circulants chez des patients autrement diagnostiqués pour un myélome multiple. Nous rapportons dans ce travail cinq cas de LP colligés au laboratoire d'hématologie du Centre hospitalier universitaire Mohammed VI d'Oujda. L'intérêt de ce travail est d'élucider l'importance de la cytologie hématologique dans l'orientation diagnostique ainsi que l'innovation thérapeutique concernant cette pathologie rare.
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Taxonomy
TopicsMultiple Myeloma Research and Treatments · Amyloidosis: Diagnosis, Treatment, Outcomes · Chronic Lymphocytic Leukemia Research