# Differential Induction of Endoplasmic Reticulum Stress Signaling by Antibody Isotypes: Implications for Plasma Cell Differentiation

## TL;DR

IgE antibodies cause more endoplasmic reticulum stress than IgG1, which may influence how plasma cells develop.

## Contribution

The study identifies the Cε3 domain of IgE as a key driver of ER stress through enhanced BiP binding.

## Key findings

- IgE induces stronger ER stress compared to IgG1 due to its Cε3 domain.
- IRE1-XBP1 signaling links ER stress to plasma cell differentiation.
- IgE's unique properties suggest specific roles in immune responses.

## Abstract

IgE induces stronger ER stress than IgG1 due to its constant region, particularly the Cε3 domain, which binds BiP more efficiently. Genetic and structural analyses confirmed IgE's higher BiP‐binding capacity. ER stress, driven by IRE1‐XBP1 signaling, regulates plasma cell differentiation, suggesting IgE‐specific mechanisms in immune responses.