# Preregistered multi-site preclinical randomized controlled trials: the beginning of a new day in reverse translational science?

**Authors:** Lorenzo Leggio, Giancarlo Colombo

PMC · DOI: 10.1038/s41386-025-02090-7 · 2025-03-20

## Full-text entities

- **Diseases:** AUD (MESH:D000437), addiction (MESH:D019966)
- **Chemicals:** heroin (MESH:D003932), alcohol (MESH:D000438), R-ketamine (-), acamprosate (MESH:D000077443)
- **Species:** Rattus norvegicus (brown rat, species) [taxon 10116], Homo sapiens (human, species) [taxon 9606]

---
Source: https://tomesphere.com/paper/PMC12032300