# The Special Issue “The 20th Anniversary of Pharmaceuticals—Multi-Targeted Natural Products as Therapeutics” Editorial—Multi-Targeted Therapeutics from Natural Sources: What Do We Know?

**Authors:** Elena Y. Enioutina, Katheleen M. Job, Catherine M. Sherwin

PMC · DOI: 10.3390/ph18040442 · Pharmaceuticals · 2025-03-21

## Full-text entities

- **Genes:** STAT3 (signal transducer and activator of transcription 3) [NCBI Gene 6774] {aka ADMIO, ADMIO1, APRF, HIES}, PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) [NCBI Gene 5291] {aka P110BETA, PI3K, PI3KBETA, PIK3C1}, ATPase [NCBI Gene 3654511]
- **Diseases:** Inflammatory (MESH:D007249), injury to (MESH:D014947), Respiratory Tract Infections (MESH:D012141), Skin Conditions (MESH:D012871), Pain (MESH:D010146), malignancies (MESH:D009369), Lung Carcinoma (MESH:D008175), Asthma (MESH:D001249), tuberculosis (MESH:D014376), metastasis (MESH:D009362), infection (MESH:D007239), Benign Prostatic Hyperplasia (MESH:D011470)
- **Chemicals:** terpenoids (MESH:D013729), Catechins (MESH:D002392), Essential Oils (MESH:D009822), Testosterone (MESH:D013739), artemisinin (MESH:C031327), ginsenosides (MESH:D036145), silymarin (MESH:D012838), taxol (MESH:D017239), polysaccharides (MESH:D011134), Glucans (MESH:D005936), polyphenols (MESH:D059808), Pentacyclic Triterpenes (MESH:D053978), lipid (MESH:D008055), LPS (MESH:D008070), Caffeic Acid (MESH:C040048), Beta-glucans (MESH:D047071), cannabidiol (MESH:D002185), glucose (MESH:D005947), CBD (-), cyclosporine (MESH:D016572), doxorubicin (MESH:D004317), Podocarpusflavone A (MESH:C094150)
- **Species:** Bursera microphylla (species) [taxon 80317], Silybum marianum (blessed milkthistle, species) [taxon 92921], Cannabis sativa (species) [taxon 3483], Bacillus subtilis (species) [taxon 1423], Pelargonium sidoides (species) [taxon 1417791], Escherichia coli (E. coli, species) [taxon 562], Pseudomonas aeruginosa (species) [taxon 287], Thymus vulgaris (common thyme, species) [taxon 49992], Dioscorea polystachya (Chinese yam, species) [taxon 55575], Andrographis paniculata (species) [taxon 175694], Hypericum perforatum (species) [taxon 65561], Cichorium intybus (chicory, species) [taxon 13427], Panax notoginseng (notoginseng, species) [taxon 44586], Primula veris (cowslip, species) [taxon 170927], Actinopterygii (fishes, superclass) [taxon 7898], Primula elatior (oxlip, species) [taxon 175059], Prunella vulgaris (common self-heal, species) [taxon 39358], Centella asiatica (Asiatic pennywort, species) [taxon 48106], Echinacea (genus) [taxon 53747], Danio rerio (leopard danio, species) [taxon 7955], Phaeophyceae (brown algae, class) [taxon 2870], Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], Kielmeyera membranacea (species) [taxon 2508376], Staphylococcus aureus (species) [taxon 1280], Rattus norvegicus (brown rat, species) [taxon 10116], Mycobacterium marinum (species) [taxon 1781], Candida [taxon 1535326], Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** RAW264.7 — Mus musculus (Mouse), Mouse leukemia, Cancer cell line (CVCL_0493)

## Full text

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## References

22 references — full list in the complete paper: https://tomesphere.com/paper/PMC12030276/full.md

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Source: https://tomesphere.com/paper/PMC12030276