# Influence of Occult Hepatitis B Infection on Blood Transfusion Safety and Its Countermeasures

**Authors:** Meng Yi, Shuchang Dai, Lin Fang, Bo Pan, Bin Fan, Yiming Pan, Zhong Liu

PMC · DOI: 10.3390/pathogens14040301 · Pathogens · 2025-03-21

## TL;DR

This paper discusses how occult hepatitis B infection poses a risk to blood transfusion safety and emphasizes the need for better monitoring and management.

## Contribution

The paper highlights the importance of addressing occult hepatitis B infection in blood transfusion safety, particularly in China.

## Key findings

- Occult hepatitis B infection can lead to virus transmission during blood transfusions.
- China's blood-screening technology has advanced, but OBI remains a hidden danger.
- Strengthening OBI monitoring is crucial for blood safety and public health.

## Abstract

Occult hepatitis B infection (OBI) is a serious public health issue. Although a number of effective hepatitis B vaccines are available, hepatitis B still poses a threat to global public health. Patients with OBI are usually asymptomatic, but there may be active HBV DNA present in their blood, leading to the risk of virus transmission during blood transfusions or organ transplantation, constituting a hazard to the health of recipients and increasing the risk of liver cirrhosis and liver cancer. Although China has progressed in the development of blood-screening technology, OBI is still a significant hidden danger to blood transfusion safety. Therefore, in blood screening and blood transfusion, strengthening the monitoring and management of OBI is crucial to ensure blood safety and protect public health.

## Linked entities

- **Diseases:** hepatitis B (MONDO:0005344), liver cancer (MONDO:0002691)

## Full-text entities

- **Diseases:** OBI (MESH:D006509), liver cancer (MESH:D006528), liver cirrhosis (MESH:D008103)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

112 references — full list in the complete paper: https://tomesphere.com/paper/PMC12030072/full.md

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Source: https://tomesphere.com/paper/PMC12030072