Role of Nutritional Status in Acute Coronary Syndrome Patients with Diabetes

TL;DR

This study shows that diabetes affects the nutritional status and metabolic parameters of acute coronary syndrome patients, with lower albumin and higher triglycerides observed.

Contribution

The study introduces the Prognostic Nutrition Index (PNI) as a potential tool for predicting cardiovascular complications in diabetic ACS patients.

Findings

Diabetic patients had significantly higher glucose and triglyceride levels compared to non-diabetic patients.

Lower hemoglobin, albumin, and PNI scores were observed in patients with diabetes.

Triglyceride and neutrophil levels were higher in NSTEMI patients with diabetes.

Abstract

Background and Objectives: This study aims to investigate the effect of Type 2 diabetes mellitus (DM) on nutritional status in acute coronary syndrome (ACS) patients and its relationship with various metabolic and hematologic parameters. Materials and Methods: A retrospective and cross-sectional design was used to analyze 485 acute coronary syndrome (ACS) patients who underwent angiography at Fethi Sekin City Hospital between 1 January 2020 and 1 January 2025. Clinical data, biochemical parameters (hemogram, glucose, creatinine, uric acid, lactate dehydrogenase (LDH), albumin, and cholesterol levels) were retrospectively analyzed. The Prognostic Nutrition Index (PNI) and CONUT score were calculated manually. Results: A total of 485 patients were included in this study. Patients were divided into two groups: patients with DM (n = 167) and patients without DM (n = 318). Glucose levels (p < 0.001) and triglyceride levels (p = 0.014) were significantly higher in patients with diabetes, while LDL cholesterol and total cholesterol levels were lower (p < 0.01). In addition, hemoglobin (p < 0.001), albumin (p = 0.010), and PNI scores (p = 0.014) were lower in patients with diabetes. Although CONUT scores were higher in patients with diabetes, this difference was not statistically significant (p = 0.267). Significant differences were observed in lipid profile and inflammation parameters in STEMI and NSTEMI subgroups, especially in patients with diabetes. In particular, triglyceride and neutrophil levels were found to be higher in NSTEMI patients among patients with diabetes. Conclusions: The PNI score may be a useful prognostic tool for predicting cardiovascular complications and determining treatment strategies in acute coronary syndrome patients with diabetes mellitus in whom nutritional status, inflammation, and lipid metabolism are significantly correlated.

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