# CPDP: Contrastive Protein–Drug Pre-Training for Novel Drug Discovery

## TL;DR

CPDP is a new method that improves the prediction of drug-target interactions, especially for novel drugs, using contrastive learning and multi-dimensional representations.

## Contribution

CPDP introduces a novel pre-training framework that enables zero-shot learning for drug discovery using contrastive learning and multi-dimensional representations.

## Key findings

- CPDP achieves high accuracy in predicting drug-target interactions for novel drugs not seen in training data.
- The model shows strong generalization and maintains effectiveness for traditional drug repositioning tasks.
- Contrastive learning enhances the alignment of protein and drug representations, improving prediction performance.

## Abstract

Novel drug discovery and repositioning remain critical challenges in biomedical research, requiring accurate prediction of drug–target interactions (DTIs). We propose the CPDP framework, which builds upon existing biomedical representation models and integrates contrastive learning with multi-dimensional representations of proteins and drugs to predict DTIs. By aligning the representation space, CPDP enables GNN-based methods to achieve zero-shot learning capabilities, allowing for accurate predictions of unseen drug data. This approach enhances DTI prediction performance, particularly for novel drugs not included in the BioHNs dataset. Experimental results demonstrate CPDP’s high accuracy and strong generalization ability in predicting novel biological entities while maintaining effectiveness for traditional drug repositioning tasks.