# Infective or Non-Infective Endocarditis: A Brief Literature Review Based on a Case Report

**Authors:** Vasiliki Tsolaki, George E. Zakynthinos, Konstantina Deskata, Ilias Dimeas, Kyriaki Parisi, Athanasia Makrygianni, Grigorios Giamouzis, Epaminondas Zakynthinos, Andrew Xanthopoulos

PMC · DOI: 10.3390/jcm14082675 · 2025-04-14

## TL;DR

This paper presents a case of a patient with multiple valve lesions and fever, exploring whether the condition is infective or non-infective endocarditis.

## Contribution

The novelty lies in the detailed case presentation combined with a literature review to differentiate between infective and non-infective endocarditis.

## Key findings

- The patient had lesions on multiple heart valves and a history of multiple myeloma.
- The report highlights the challenges in diagnosing endocarditis in immunocompromised patients.
- Clinical questions and literature review are used to guide the diagnostic process.

## Abstract

In the present report, we describe a patient presenting in the intensive care unit with fever, respiratory failure, and multiple lesions on cardiac valves. The patient, with a history of multiple myeloma under treatment, was intubated due to ARDS from influenza, and cardiac ultrasonography revealed lesions in the aortic, mitral, and tricuspid valves. There is a step-by-step approach in the case presentation, with clinical questions, while there is a review of the current literature concerning the issue.

## Linked entities

- **Diseases:** multiple myeloma (MONDO:0009693), influenza (MONDO:0005812), ARDS (MONDO:0006502), endocarditis (MONDO:0005025)

## Full-text entities

- **Diseases:** influenza (MESH:D007251), Endocarditis (MESH:D004696), ARDS (MESH:D012128), fever (MESH:D005334), respiratory failure (MESH:D012131), multiple myeloma (MESH:D009101)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12027718/full.md

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Source: https://tomesphere.com/paper/PMC12027718