A Review of Food Bioactives That Can Modulate miRNA Profiles for Management of Colorectal Cancer

TL;DR

This review explores how food bioactives like curcumin and resveratrol can modulate miRNAs to help manage colorectal cancer.

Contribution

The paper provides a comprehensive review of how dietary bioactives influence miRNA profiles in colorectal cancer.

Findings

Food bioactives modulate miRNAs to impact CRC cell behavior.

Components like curcumin and resveratrol influence CRC cell proliferation and apoptosis.

Regulating miRNA expression through diet offers new CRC treatment directions.

Abstract

Colorectal cancer (CRC), the third leading cause of cancer globally, with high mortality, necessitates more effective treatments and adjunct therapies. MicroRNAs (miRNAs), short non-coding RNAs, regulate gene expression. Food-derived active components have the potential to modulate CRC cellular processes, aiding in the prevention and management of CRC. This review explores the role of miRNAs in CRC and summarizes the anti-inflammatory, antioxidant, and pro-apoptotic effects of typical food bioactive components by modulating specific miRNAs. We investigate the potential and scientific basis of regulating miRNA expression through dietary therapy and preventive approaches, providing new directions for CRC treatment. Collectively, miRNAs regulate gene expression, impacting the onset, progression, metastasis, and treatment response of CRC. Food components such as curcumin and resveratrol modulate specific miRNAs, affecting CRC cell behavior. Bioactive food components influence CRC cell proliferation, apoptosis, and drug sensitivity by regulating key proteins and pathways.

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