# The Impact of Peri-Operative Nutritional Status on Survival in Gastroesophageal Adenocarcinoma

## TL;DR

This study shows that maintaining good nutrition before and after surgery improves survival in patients with gastroesophageal cancer.

## Contribution

The study demonstrates that peri-operative nutritional status and weight loss significantly affect survival outcomes in GOC patients.

## Key findings

- Lower post-operative nutritional status correlated with worse overall survival (p < 0.001).
- Patients who improved or maintained nutritional status had better survival (HR: 2.7; p = 0.01).
- Weight loss of more than 10% was linked to shorter survival (HR: 2.2; p = 0.009).

## Abstract

In patients with gastric, gastroesophageal junction or esophageal adenocarcinoma (GOC), peri-operative multimodal therapies have improved survival; however, prognosis remains underwhelming. Pre-operative nutritional decline and weight are linked with poorer patient outcomes. This study retrospectively analyzed the impact of peri-operative nutritional status (as assessed by patient-generated subjective global assessment, PG-SGA), and weight loss on the survival of patients undergoing curative surgery for GOC (2013 to 2022). Of the 148 patients who underwent surgery, PG-SGA and weight data were available for 107 (72%) and 121 (82%), respectively. At presentation, 44% (n = 47) of patients were well nourished, dropping to 17% (n = 18) post-operatively. Lower post-operative nutritional status correlated to worse overall survival (OS) (p < 0.001). Patients who stayed well nourished or improved their nutritional status had better survival outcomes (HR: 2.7; 95%CI: 1.2–6.1; p = 0.01). Significant weight loss (>10%) was ubiquitously observed in 54% (n = 64) of patients, and this group had shorter OS (HR: 2.2; 95%CI: 1.2–4.1; p = 0.009). In conclusion, both nutritional decline and weight loss negatively impacted survival. Maintenance of nutritional status over the peri-operative period resulted in better outcomes. This study highlights the need for improved nutritional support during curative treatment in GOC.