# Perspectives on Outpatient Delivery of Bispecific T-Cell Engager Therapies for Multiple Myeloma

## TL;DR

This review discusses the outpatient delivery of T-cell engager therapies for multiple myeloma, highlighting their benefits and challenges.

## Contribution

The paper outlines key requirements and management strategies for outpatient delivery of TCE therapies in multiple myeloma.

## Key findings

- T-cell engagers show sustained efficacy and progression-free survival benefits in heavily treated myeloma patients.
- Complications like cytokine release syndrome and neurotoxicity complicate TCE administration in remote centers.
- The paper provides guidance on managing acute and chronic complications of TCE therapy.

## Abstract

In the past few years, a new promising therapy, called bispecific T-cell engager (TCE), has been developed and is now available in many countries for patients with relapsed or refractory multiple myeloma. T-cell engagers are associated with sustained efficacy and progression-free survival benefits in patients with heavily treated myeloma. However, complications such as cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), and infections complicate their administration, particularly in remote centers. This review discusses the key requirements for delivering TCEs therapies, focusing on outpatient delivery. We also outline the primary acute and chronic complications of TCE therapy and their management.