# Glioblastoma in NF1: A Unique Entity—A Literature Review Focusing on Surgical Implication and Our Experience

## TL;DR

Glioblastoma in NF1 patients is a unique type that may respond better to treatment and lead to longer survival compared to typical glioblastoma.

## Contribution

The paper presents two long-survival cases of NF1-associated GBM and suggests better outcomes compared to non-NF1 GBM.

## Key findings

- NF1-associated GBM patients may have better responses to standard therapy.
- Two NF1 patients with GBM survived 117 and 25 months after treatment.
- NF1-associated GBM could be considered a distinct entity with better prognosis.

## Abstract

Glioblastoma in patients affected by NF1 germline mutation (NF1-associated GBM) represents a unique heterogeneous clinical and pathological entity. We have reviewed the few cases reported in the literature and they seem to have a better response to standard therapy and overall survival than GBM in the non-NF1 population. We present two cases of long-survival NF1 patients with GBM. Case 1 was a 38-year-old woman with cerebellar GBM who underwent surgical asportation and the Stupp protocol many times with an overall survival of 117 months. Case 2 was a 47-year-old woman with GBM in the eloquent area of the right frontal lobe; she underwent surgical asportation and the Stupp protocol with an overall survival of 25 months. The data analysis demonstrates that NF1-associated GBM patients could be considered long-term survivors.