# Iatrogenic Dementia: Providing Insight into Transmissible Subtype of Alzheimer’s Disease, Creutzfeldt–Jakob Disease and Cerebral Amyloid Angiopathy

## TL;DR

This paper reviews iatrogenic dementia, a rare form of Alzheimer's, CJD, and CAA caused by medical procedures, emphasizing its early onset and prion-like transmission.

## Contribution

The paper identifies iatrogenic dementia as a new disease entity requiring individualized investigation and clinical awareness.

## Key findings

- Iatrogenic dementia is linked to medical or surgical procedures and shows early onset.
- It exhibits a prion-like transmission pattern and distinct clinical features.
- The condition poses a significant challenge in diagnosing AD, CJD, and CAA.

## Abstract

Within the phenotypic spectrum of Alzheimer’s disease (AD), Creutzfeldt–Jakob disease (CJD) and cerebral amyloid angiopathy (CAA), dementia that is attributed to iatrogenic transmission has increasingly gained scientific attention recently. Newly recognized, this treatment-induced form of dementia may result from exposure to certain medical or surgical procedures. The present review aims to explore the distinct features of acquired dementia encompassing a history of potential exposure and relatively early age of onset, highlighting transmission potential with a rather prion-like pattern. Having reviewed all available relevant literature, dementia of iatrogenic etiology represents a new disease entity that requires an individualized investigation process and poses a great clinical challenge as far as patients with AD, CJD and CAA are concerned. Understanding the underlying pathophysiology of these rare forms of dementia may significantly enhance awareness within clinical field of neurodegenerative diseases and facilitate their prompt management.