# Virtual Therapy Planning of Aortic Valve Replacement for Preventing Patient-Prosthesis Mismatch

## TL;DR

This study uses virtual simulations to show that larger aortic valve prostheses and physical activity affect post-surgery blood flow and pressure gradients, helping avoid patient-prosthesis mismatch.

## Contribution

The study introduces virtual therapy planning with computational fluid dynamics to predict patient-prosthesis mismatch outcomes after aortic valve replacement.

## Key findings

- Larger valve sizes significantly reduced pressure gradients across the aortic valve compared to smaller sizes.
- Physical activity simulations increased pressure gradients across all valve sizes, indicating residual stenosis.
- Blood flow profiles in the ascending aorta remained abnormal after surgery and were unaffected by physical activity.

## Abstract

Background: Recent studies suggest that any degree of patient-prosthesis mismatch (PPM) increases morbidity and mortality after surgical aortic valve replacement (SAVR). We used computational fluid dynamics simulations to test the influence of prosthesis size and physical activity after SAVR. Methods: In 10 patients with aortic valve stenosis, virtual SAVR was performed. Left ventricular outflow tract stroke volume and flow direction information (4D Flow) were used, and an increase in stroke volume of 25% was chosen for simulating physical activity. Pressure gradients (DP max) across the aortic valve and blood flow profiles in the ascending aorta were calculated and predicted for three different valve sizes at rest and under stress in every patient. Results: Gradients across the aortic valve were significantly lower using larger valves; however, they were not normalized after SAVR (DP max [mmHg] norm/smaller/reference/larger valve = 6/14/12/9 mmHg, <0.01 compared to norm). Physical activity simulation increased DP max in all patients and across all valve sizes (DP max [mmHg] rest versus stress for the smaller/reference/larger valve = 14 vs. 23, 12 vs. 18, 9 vs. 14). Blood flow profiles did not normalize after SAVR and remained unaffected by physical activity. Gradients differed between mild and moderate stenosis between different therapy options and even showed moderate to severe stenosis under simulated physical activity. Conclusions: Prosthesis size and physical activity simulation have a significant influence on gradients across the aortic valve. Virtual therapy planning using patient-specific data might help to improve outcomes after SAVR in the future.