# Local Extremum Mapping for Weak Supervision Learning on Mammogram Classification and Localization

**Authors:** Minjuan Zhu, Lei Zhang, Lituan Wang, Zizhou Wang, Yan Wang, Guangwu Qian

PMC · DOI: 10.3390/bioengineering12040325 · Bioengineering · 2025-03-21

## TL;DR

A new method called Local Extremum Mapping helps detect breast lesions in mammograms using only image-level labels, reducing the need for costly detailed annotations.

## Contribution

The novel Local Extremum Mapping mechanism enables weakly supervised lesion localization and classification in mammograms.

## Key findings

- The proposed LEM method achieves 96.3% classification accuracy on the INbreast dataset.
- LEM outperforms Grad-CAM with a dice similarity coefficient of 0.37 for lesion localization.
- The method reduces annotation costs by using only image-level labels for training.

## Abstract

The early and accurate detection of breast lesions through mammography is crucial for improving survival rates. However, the existing deep learning-based methods often rely on costly pixel-level annotations, limiting their scalability in real-world applications. To address this issue, a novel local extremum mapping (LEM) mechanism is proposed for mammogram classification and weakly supervised lesion localization. The proposed method first divides the input mammogram into multiple regions and generates score maps through convolutional neural networks. Then, it identifies the most informative regions by filtering local extrema in the score maps and aggregating their scores for final classification. This strategy enables lesion localization with only image-level labels, significantly reducing annotation costs. Experiments on two public mammography datasets, CBIS-DDSM and INbreast, demonstrate that the proposed method achieves competitive performance. On the INbreast dataset, LEM improves classification accuracy to 96.3% with an AUC of 0.976. Furthermore, the proposed method effectively localizes lesions with a dice similarity coefficient of 0.37, outperforming Grad-CAM and other baseline approaches. These results highlight the practical significance and potential clinical applications of our approach, making automated mammogram analysis more accessible and efficient.

## Linked entities

- **Diseases:** breast cancer (MONDO:0004989)

## Full-text entities

- **Diseases:** breast lesions (MESH:D061325)

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12024162/full.md

## References

62 references — full list in the complete paper: https://tomesphere.com/paper/PMC12024162/full.md

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Source: https://tomesphere.com/paper/PMC12024162