# Deep Brain Stimulation for Post-Hypoxic Myoclonus: A Case Correlating Local Field Potentials to Clinical Outcome

## TL;DR

This paper presents a case where deep brain stimulation improved myoclonus after brain injury and linked the improvement to brain activity patterns.

## Contribution

The first case to correlate local field potentials with clinical improvement in post-hypoxic myoclonus using DBS sensing.

## Key findings

- Clinical improvement in myoclonus was observed after 6 months of DBS.
- Local field potential activity correlated with the improvement in symptoms.
- DBS shows potential as a treatment for medically refractory post-hypoxic myoclonus.

## Abstract

Post-hypoxic myoclonus (PHM) is characterized by generalized myoclonus after hypoxic brain injury. PHM is often functionally impairing and refractory to medical therapies. There are a handful of reports utilizing deep brain stimulation (DBS) to treat medically refractory PHM.

A 56-year-old woman developed PHM following an anoxic brain injury. Utilizing a stimulating and sensing DBS system, we show clinical improvement in myoclonus at 6 months and correlate it to local field potential (LFP) activity.

We present the first case to utilize DBS sensing to correlate LFP activity to myoclonus improvement. Our case contributes to the growing evidence of DBS for PHM.