# Antidepressants and antibiotic resistance in urine cultures: a cohort study

## TL;DR

This study finds a link between antidepressant use and antibiotic resistance in urine samples from emergency department patients.

## Contribution

The study provides epidemiological evidence supporting in vitro findings of antidepressant-induced antibiotic resistance.

## Key findings

- Antidepressant use is significantly associated with antibiotic resistance in urine cultures.
- The findings support previous in vitro evidence of antidepressant-driven resistance.
- The study raises new questions about the clinical implications of antidepressant use on antibiotic resistance.

## Abstract

In vitro evidence of antidepressant-driven antibiotic resistance has recently been described. In this retrospective cohort study, significant associations are identified between antidepressant use and antibiotic resistance on urine cultures taken in the Emergency Department. This epidemiologic data supports previous in vitro work and raises additional questions for further study.