A Case of Non‐Small‐Cell Lung Cancer With Massive Malignant Ascites Treated With Chemotherapy Combined With Cell‐Free and Concentrated Ascites Reinfusion Therapy

TL;DR

A new treatment combining chemotherapy and ascites reinfusion improved symptoms in a lung cancer patient with severe fluid buildup.

Contribution

First reported use of CART combined with chemotherapy for malignant ascites in lung cancer.

Findings

CART reduced abdominal distention and slowed ascites accumulation.

CART increased blood albumin levels and allowed prolonged chemotherapy.

This approach may offer a novel treatment option for lung cancer with malignant ascites.

Abstract

We report the case of a 65‐year‐old woman with stage IVB lung adenocarcinoma who developed malignant ascites during treatment. Despite multiple ascitic fluid drainages and second‐line chemotherapy, the ascites progressively worsened. The initiation of cell‐free and concentrated ascites reinfusion therapy (CART) led to improved abdominal distention, increased blood albumin levels, and slower ascites accumulation. To our knowledge, this is the first report of CART combined with chemotherapy for the management of malignant ascites associated with lung cancer.

A 65‐year‐old woman with stage IVB lung adenocarcinoma developed progressive malignant ascites despite conventional drainage and chemotherapy. Cell‐free and concentrated ascites reinfusion therapy (CART) was initiated; it relieved symptoms, increased serum albumin levels, and reduced ascites accumulation, allowing prolonged chemotherapy. This is the first reported case of CART combined with chemotherapy for malignant ascites in lung cancer.

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