# Chasing the High, Losing the Beat: A Case of Cocaine-Induced Myocardial Infarction

**Authors:** Saurabh Kumar Singh, Chirag Agrawal, Anbhigya Kumar Arya, Satyajit Padhiary, Devesh Kumar

PMC · DOI: 10.7759/cureus.81158 · 2025-03-25

## TL;DR

A young man suffered a heart attack after using cocaine for the first time and was successfully treated with emergency heart procedures.

## Contribution

This case report highlights the rare occurrence of cocaine-induced myocardial infarction in a young, previously healthy individual.

## Key findings

- A young male experienced an anterior wall myocardial infarction shortly after first-time cocaine use.
- Emergency coronary angiography revealed a severe blockage and thrombus, successfully treated with PCI.
- The patient had a favorable outcome with proper follow-up and adherence to therapy.

## Abstract

Cocaine use is a well-established risk factor for various cardiovascular complications, including acute myocardial infarction (MI). The pathophysiological mechanisms responsible for cocaine-induced MI are multifactorial, encompassing coronary vasoconstriction, increased myocardial oxygen demand, and thrombosis. While cocaine-related cardiovascular events are more commonly seen in individuals with pre-existing risk factors, cases involving young, otherwise healthy individuals remain rare, yet they present a significant concern. We present the case of a young male in his late teens who presented to the emergency department with acute-onset chest pain that began two hours following his first-time use of cocaine. On evaluation, it was an anterior wall MI. Urgent coronary angiography was performed, which showed an ostial cut-off in the left anterior descending artery, along with a Thrombolysis in Myocardial Infarction (TIMI) grade V thrombus. Percutaneous coronary intervention (PCI) was successfully performed, and TIMI III flow was achieved. He was discharged on day five post-procedure, and at a six-month follow-up, he was doing well. This case highlights the need for early recognition and prompt intervention, including coronary angiography and PCI, to improve outcomes. Furthermore, it emphasizes the potential for long-term success with proper follow-up care and adherence to prescribed therapies.

## Linked entities

- **Chemicals:** cocaine (PubChem CID 2826)
- **Diseases:** myocardial infarction (MONDO:0005068)

## Full-text entities

- **Diseases:** MI (MESH:D009203), chest pain (MESH:D002637), cardiovascular complications (MESH:D002318), thrombosis (MESH:D013927)
- **Chemicals:** Cocaine (MESH:D003042), oxygen (MESH:D010100)

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12021012/full.md

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Source: https://tomesphere.com/paper/PMC12021012