# Safety and efficacy of a feed additive consisting of xylanase (produced with Komagataella phaffii DSM 25376) and β‐glucanase (produced with Komagataella phaffii DSM 26469) (ENZY CARBOPLUS®) for all poultry (Kaesler Nutrition GmbH)

**Authors:** Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Ilen Röhe, Katerina Theodoridou, Baltasar Mayo, Lieve Herman, Montserrat Anguita, Nicole Bozzi Cionci, Matteo L. Innocenti, Jordi Ortuño, Elisa Pettenati

PMC · DOI: 10.2903/j.efsa.2025.9344 · 2025-04-24

## TL;DR

This paper evaluates the safety and effectiveness of a feed additive for poultry, concluding it is safe and effective for all poultry types.

## Contribution

The study confirms the safety and efficacy of ENZY CARBOPLUS® for all poultry, extending its authorized use.

## Key findings

- The additive is safe for all poultry and does not pose risks to consumers or the environment.
- The additive is a respiratory sensitiser but not a skin or eye irritant or dermal sensitiser.
- The additive is effective as a zootechnical feed additive for all poultry under proposed conditions.

## Abstract

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of xylanase (produced with Komagataella phaffii DSM 25376) and β‐glucanase (produced with Komagataella phaffii DSM 26469) (ENZY CARBOPLUS®) as a zootechnical feed additive (functional group: digestibility enhancers). The additive is already authorised for use in feed for chickens for fattening, chickens reared for laying, turkeys for fattening and all avian species reared for laying or breeding purposes. The applicant requested a modification of the terms of the current authorisation for chickens for fattening and reared for laying, as well as an extension of use to all poultry. The FEEDAP Panel concluded that the additive is safe for all poultry. The use of the additive is considered safe for the consumers and the environment. The FEEDAP Panel concluded that the additive is not a skin or eye irritant nor a dermal sensitiser, but it is considered a respiratory sensitiser. The Panel concluded that the additive has the potential to be efficacious as a zootechnical additive for all poultry under the proposed conditions of use.

## Full-text entities

- **Species:** Meleagris gallopavo (common turkey, species) [taxon 9103], Gallus gallus (bantam, species) [taxon 9031], Komagataella phaffii (species) [taxon 460519]

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Source: https://tomesphere.com/paper/PMC12018903