# Pregnancy associated cardiomyopathy in 2 cancer survivors with history of anthracycline use

**Authors:** Ramy Zughul, Navya Akula, Isaac Rhea, Michael Zacharias, Heather Blume, Chantal ElAmm

PMC · DOI: 10.1016/j.ahjo.2025.100539 · 2025-04-04

## TL;DR

This paper reports two cases of pregnancy-related heart disease in cancer survivors who previously used anthracyclines.

## Contribution

It highlights a rare occurrence of new-onset cardiomyopathy in cancer survivors during pregnancy.

## Key findings

- Pregnancy-associated cardiomyopathy occurred in two cancer survivors with prior anthracycline exposure.
- New-onset cardiomyopathy is rare but possible in this high-risk population.

## Abstract

Cardiac complications in childhood cancer survivors are increasingly recognized, with radiotherapy and anthracycline exposure being major culprits. The incidence of recurrent cardiomyopathy in this population is significant, while the incidence of new-onset cardiomyopathy remains rare. This case series presents two cases of pregnancy-associated cardiomyopathy with a history of anthracycline use.

## Linked entities

- **Diseases:** cardiomyopathy (MONDO:0004994)

## Full-text entities

- **Diseases:** Cardiac complications (MESH:D006331), cancer (MESH:D009369), cardiomyopathy (MESH:D009202)
- **Chemicals:** anthracycline (MESH:D018943)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12017966/full.md

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Source: https://tomesphere.com/paper/PMC12017966