# The role of RGS12 in tissue repair and human diseases

## TL;DR

This paper reviews the role of RGS12 in human diseases and its potential as a therapeutic target.

## Contribution

A comprehensive review of RGS12's involvement in various diseases and its therapeutic potential.

## Key findings

- RGS12 is widely expressed and affects cell activity in physiological and pathological processes.
- It plays a significant role in the pathogenesis of many diseases.
- RGS12 shows potential as a therapeutic target for treating human diseases.

## Abstract

Regulator of G protein signaling 12 (RGS12) belongs to the superfamily of RGS proteins defined by a conserved RGS domain that canonically binds and deactivates heterotrimeric G-proteins. As the largest family member, RGS12 is widely expressed in many cells and tissues. In the past few decades, it has been found that RGS12 affects the activity of various cells in the human body, participates in many physiological and pathological processes, and plays an important role in the pathogenesis of many diseases. Here, we set out to comprehensively review the role of RGS12 in human diseases and its mechanisms, highlighting the possibility of RGS12 as a therapeutic target for the treatment of human diseases.