# The rs3844492/ARHGAP22 and rs741301/ELMO1 polymorphisms are associated with changes in laboratory markers of renal damage among patients with type 2 diabetes mellitus

## TL;DR

This study found that specific genetic variations are linked to kidney damage in type 2 diabetes patients.

## Contribution

The study identifies new genetic associations with diabetic kidney disease and renal function markers.

## Key findings

- The rs3844492/ARHGAP22 G allele is linked to higher risk of diabetic kidney disease.
- The G allele is also associated with lower kidney function and higher creatinine levels.
- The rs741301/ELMO1 C allele may be linked to elevated creatinine levels in type 2 diabetes patients.

## Abstract

To investigate the association between the
rs3844492/ARHGAP22 and rs741301/ELMO1
polymorphisms and diabetic kidney disease in patients with type 2 diabetes
mellitus.

The sample consisted of 740 patients with type 2 diabetes mellitus and
diabetic kidney disease (cases) and 303 patients with type 2 diabetes
mellitus, but no diabetic kidney disease (controls). The genotyping of the
polymorphisms was conducted using real-time polymerase chain reaction with
Taqman probes.

The frequency of the rs3844492/ARHGAP22 G/G genotype was 16.8% in the control
group and 15.7% in cases (p = 0.069). After adjusting for covariables, the
presence of the G allele was associated with risk for diabetic kidney
disease (OR = 1.435, 95% CI 1.023 – 2.011; p = 0.036), as well as with a
decreased estimated glomerular filtration rate (p = 0.012) and elevated
creatinine levels (p = 0.009). No difference was observed in the
rs741301/ELMO1 genotype frequencies between groups (p = 0.800). However, the
presence of the C allele appears to be associated with higher creatinine
levels in patients with type 2 diabetes mellitus (p = 0.064).

The rs3844492/ARHGAP22 and rs741301/ELMO1
polymorphisms are associated with alterations in renal function markers
among patients with type 2 diabetes mellitus.