# Massive Osteolysis of the Mandible in Gorham’s Disease: Our Case Experience

**Authors:** Balaji Jayaraman, Arunkumar Kamalakaran, Dakshayani Balaji, Kamalakannan Padmanaban, Vignesh Senthilkumar, Naif Ahamed

PMC · DOI: 10.7759/cureus.81063 · 2025-03-24

## TL;DR

This paper presents a rare case of bone loss in the jaw of a 14-year-old, highlighting the challenges in diagnosing Gorham’s disease.

## Contribution

The novelty lies in documenting a new case of Gorham’s disease in the mandible with tooth loosening in a teenage patient.

## Key findings

- Gorham’s disease was diagnosed in a 14-year-old male with progressive bone loss in the right mandible.
- The case highlights the difficulty in diagnosing the disease due to its rarity and atypical presentation.
- The patient exhibited tooth loosening as a key clinical feature.

## Abstract

Vanishing bone disease is an exceptionally rare condition marked by the progressive loss of bone, ultimately leading to its complete disappearance. The cause of this disease remains unknown, and it primarily affects the axial skeleton, pelvis, and humerus. Due to its atypical presentation and rarity, it is often mistaken for other disorders, making an accurate diagnosis challenging and typically a process of elimination. Gorham’s disease has been documented in the maxillofacial region, with most involving the mandible. We present a case involving a 14-year-old male patient who exhibited Gorham’s disease in the right mandible, characterized by the loosening of teeth.

## Linked entities

- **Diseases:** Gorham’s disease (MONDO:0003157), vanishing bone disease (MONDO:0007414)

## Full-text entities

- **Diseases:** Vanishing bone disease (MESH:D001847), Osteolysis (MESH:D010014), Gorham's Disease (MESH:D010015)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12015763/full.md

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Source: https://tomesphere.com/paper/PMC12015763