Dynamic and Static Functional Gradient in Temporal Lobe Epilepsy With Hippocampal Sclerosis Versus Healthy Controls

TL;DR

This study compares brain connectivity patterns in people with temporal lobe epilepsy and healthy individuals, finding disrupted brain gradients linked to cognitive decline.

Contribution

The paper introduces a novel analysis of dynamic and static brain gradients in TLE patients with hippocampal sclerosis.

Findings

TLE patients show lower dynamic recruitment of brain gradients compared to healthy controls.

Atypical activation-gradient correlations in TLE are linked to cognitive impairment.

Principal gradient reconfiguration is not driving activation reorganization in TLE.

Abstract

The gradient captures the continuous transitions in connectivity, representing an intrinsic hierarchical architecture of the brain. Previous works hinted at the dynamics of the gradient but did not verify them. Cognitive impairment is a common comorbidity of temporal lobe epilepsy (TLE). Gradient techniques provide a framework that could promote the understanding of the neural correlations of cognitive decline.

Thirty patients with TLE and hippocampal sclerosis and 29 matched healthy controls (HC) were investigated with verbal fluency task‐based functional MRI and gradient techniques. The correlation between task‐based activation/deactivation and healthy gradients, task‐based gradients, and dynamic features calculated with sliding window approaches was compared between HC and TLE.

The allegiance in the real data of HC and TLE was more widespread compared to static null models. TLE has lower dynamic recruitment of gradient, atypical activation‐gradient correlation, and contracted principal gradient. Correlation analysis proved that the reconfiguration of principal gradient did not drive the reorganization of activation. The atypical activation pattern and impaired recruitment were correlated with cognition scales in TLE.

The principal gradient is dynamic. TLE disrupted activation/deactivation patterns, the principal gradient, and the dynamics of the gradient, which were correlated with cognitive decline.

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