# RETRACTION: The Mechanism of TDP‐43 Gene Expression on Inflammatory Factors and the JNK and p38 MAPK Signalling Pathways in Ischaemic Hypoxic Stress Dependence

PMC · DOI: 10.1111/iwj.70634 · 2025-04-23

## TL;DR

This retracted paper originally claimed to explore how TDP-43 gene expression affects inflammation and signaling pathways under ischaemic hypoxic stress.

## Contribution

The paper's findings are retracted due to a compromised peer review process and incomplete ethical approval information.

## Key findings

- The article was retracted due to a compromised peer review process.
- Incomplete ethical approval information for animal experiments was found.
- The authors did not respond to the retraction notice.

## Abstract

RETRACTION:

HuangH.
, 
ZhangZ.F.
, 
QinF.W.
, 
TangW.
, 
LiuD.H.
, 
WuP.Y.
, and 
JiaoF.
, “The Mechanism of TDP‐43 Gene Expression on Inflammatory Factors and the JNK and p38 MAPK Signalling Pathways in Ischaemic Hypoxic Stress Dependence,” International Wound Journal
16, no. 3 (2019): 724–729, 10.1111/iwj.13087.30784197
PMC7949179

The above article, published online on 19 February 2019, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor in Chief, Professor Keith Harding; and John Wiley & Sons Ltd. Following an investigation by the publisher, all parties have concluded that this article was accepted solely on the basis of a compromised peer review process. In addition, further investigation by the publisher found that the authors provided incomplete ethical approval information for animal experiments performed in the study. The editors have therefore decided to retract the article. The authors did not respond to our notice regarding the retraction.

## Linked entities

- **Genes:** TARDBP (TAR DNA binding protein) [NCBI Gene 23435]

## Full-text entities

- **Genes:** MAPK8 (mitogen-activated protein kinase 8) [NCBI Gene 5599] {aka JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8}, TARDBP (TAR DNA binding protein) [NCBI Gene 23435] {aka ALS10, TDP-43}
- **Diseases:** Hypoxic Stress Dependence (MESH:D000079225)

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Source: https://tomesphere.com/paper/PMC12015127