# RETRACTION: Innate Immune Molecule Surfactant Protein D Attenuates Sepsis‐Induced Acute Kidney Injury Through Modulating Apoptosis and Nfκb‐Mediated Inflammation

PMC · DOI: 10.1111/iwj.70636 · 2025-04-23

## TL;DR

This retracted paper claimed that surfactant protein D reduces kidney damage in sepsis by affecting cell death and inflammation.

## Contribution

The paper proposed a novel mechanism involving surfactant protein D in sepsis-induced kidney injury.

## Key findings

- Surfactant protein D was suggested to modulate apoptosis in kidney cells.
- Nfκb-mediated inflammation was reported to be reduced by surfactant protein D.

## Abstract

RETRACTION:

LuS.‐J.
, 
XuJ.‐H.
, 
HeZ.‐F.
, 
WuP.
, 
NingC.
, and 
LiH.‐Y.
, “Innate Immune Molecule Surfactant Protein D Attenuates Sepsis‐Induced Acute Kidney Injury Through Modulating Apoptosis and Nfκb‐Mediated Inflammation,” International Wound Journal
17, no. 1 (2020): 100–106, 10.1111/iwj.13237.31701658
PMC7949018

The above article, published online on 08 November 2019, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor in Chief, Professor Keith Harding; and John Wiley & Sons Ltd. Following an investigation by the publisher, all parties have concluded that this article was accepted solely on the basis of a compromised peer review process. In addition, further investigation by the publisher found that the authors provided incomplete ethical approval information for animal experiments performed in the study. The editors have therefore decided to retract the article. The authors did not respond to our notice regarding the retraction.

## Linked entities

- **Proteins:** NFKB1 (nuclear factor kappa B subunit 1)
- **Diseases:** acute kidney injury (MONDO:0002492)

## Full-text entities

- **Genes:** SFTPD (surfactant protein D) [NCBI Gene 6441] {aka COLEC7, PSP-D, SFTP4, SP-D}, NFKB1 (nuclear factor kappa B subunit 1) [NCBI Gene 4790] {aka CVID12, EBP-1, KBF1, NF-kB, NF-kB1, NF-kappa-B1}
- **Diseases:** Inflammation (MESH:D007249), Sepsis (MESH:D018805), Acute Kidney Injury (MESH:D058186)

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Source: https://tomesphere.com/paper/PMC12015122