Stereological estimation of mean nuclear volume as a prognostic factor in canine subcutaneous mast cell tumors
José Catarino, Ana Macara, André Barros, David Ramilo, Filipa Coelho, Joana Santos, Pedro Faísca
TL;DR
This study shows that measuring average nuclear volume in canine mast cell tumors is reliable and can predict patient outcomes.
Contribution
The study introduces a reproducible stereological method to estimate nuclear volume as a prognostic factor in canine mast cell tumors.
Findings
Volume-weighted mean nuclear volume (vv̄) showed high reproducibility with concordance coefficients near or above 0.90.
Higher vv̄ values were significantly associated with poorer clinical outcomes in canine subcutaneous mast cell tumors.
The infiltrative tumor pattern was more common in cases with poor outcomes and higher vv̄ values.
Abstract
Classification schemes regarding canine subcutaneous mast cell tumors (csMCTs) remain elusive, lack consensus, and are prone to interobserver variability and bias. This observational study aimed to assess the reproducibility and the prognostic significance of volume-weighted mean nuclear volume ( vv¯ ), a stereological estimation offering insights into nuclear size and its variability, in csMCTs. Thirty csMCTs were selected with information regarding outcome, and vv¯ was estimated using the “point-sampled intercept” method. Interobserver and intraobserver vv¯ reproducibility yielded concordance coefficients near or above 0.90. Regarding previously reported risk factors (pattern, mitotic count, and multinucleated cells), no statistically significant differences were identified between patterns and clinical outcome, nor between patterns and vv¯ ; however, the infiltrative pattern was…
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Taxonomy
TopicsVeterinary Oncology Research · Infectious Diseases and Mycology · Tumors and Oncological Cases