# To Lyse or Not: The Role of Half‐Dose Thrombolysis in Right Ventricular Clot Associated With Sub‐Massive Pulmonary Embolism

**Authors:** Nasreldin A. Hamza, Wasfy J. Hamad, Shamim K. Vakkulathil, Vimalraj Sundaram, Haidar M. Hadi, Abdulqadir J. Nashwan

PMC · DOI: 10.1002/ccr3.70404 · 2025-04-22

## TL;DR

A 43-year-old man with a rare heart clot and lung blockage successfully recovered using half the standard clot-dissolving treatment.

## Contribution

Demonstrates successful use of half-dose thrombolysis for right ventricular clot in sub-massive pulmonary embolism.

## Key findings

- Half-dose thrombolytic therapy resolved the right ventricular clot effectively.
- The patient showed no complications after treatment.
- The case suggests half-dose thrombolysis may be a viable treatment option.

## Abstract

Right heart thrombi are rare but carry a high mortality risk. Appropriate therapy remains unclear; options include anticoagulation, thrombolysis, and surgical thrombectomy. In this case, a 43‐year‐old male with DVT, RV thrombus, and bilateral pulmonary embolism responded well to half‐dose thrombolytic therapy, with complete thrombus resolution and no complications.

## Linked entities

- **Diseases:** pulmonary embolism (MONDO:0005279)

## Full-text entities

- **Diseases:** Right heart thrombi (MESH:D006333), thrombus (MESH:D013927), DVT (OMIM:612862), Ventricular Clot (MESH:D014693), Pulmonary Embolism (MESH:D011655)

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12014510/full.md

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Source: https://tomesphere.com/paper/PMC12014510