# Case Report: Pulmonary mucormycosis caused by Rhizopus microsporus in a patient with chronic obstructive pulmonary disease

**Authors:** Shanshan Wang, Yanqing Liu, Liqing Hu, Guoqing Qian, Yijun Mo

PMC · DOI: 10.3389/fmed.2025.1544621 · 2025-04-09

## TL;DR

A rare case of pulmonary mucormycosis caused by Rhizopus microsporus is reported in a patient with chronic obstructive pulmonary disease and no other risk factors.

## Contribution

This case highlights the occurrence of mucormycosis in a patient without typical risk factors like diabetes.

## Key findings

- Pulmonary mucormycosis caused by Rhizopus microsporus was diagnosed in an 81-year-old man with COPD.
- The patient lacked traditional risk factors like diabetes or cancer.
- Despite antifungal treatment, the patient's condition worsened and led to death.

## Abstract

We report a rare case of pulmonary mucormycosis caused by Rhizopus microsporus, which is rare in patients with chronic obstructive pulmonary disease. Rhizopus microsporus had been reported as the most common etiological agent associated with human infections, except Rhizopus oryzae in some studies.

We described a case of 81-year-old man with pulmonary mucormycosis caused by Rhizopus microsporus but no other apparent risk factors including diabetes. The diagnosis mainly relied on sputum cultures and clinical manifestations. Despite antifungal therapy, his condition worsened, resulting in mortality.

In this case, the patient had no underlying diseases such as diabetes or solid tumors. Clinicians should be aware of routine pathogenic microbiological tests of pulmonary mucormycosis in patients with chronic obstructive pulmonary disease. Early and aggressive treatment can lead to improved prognosis.

## Linked entities

- **Diseases:** chronic obstructive pulmonary disease (MONDO:0005002), diabetes (MONDO:0005015)
- **Species:** Rhizopus microsporus (taxon 58291)

## Full-text entities

- **Diseases:** infections (MESH:D007239), Pulmonary mucormycosis (MESH:D009091), chronic obstructive pulmonary disease (MESH:D029424), diabetes (MESH:D003920), solid tumors (MESH:D009369)
- **Species:** Rhizopus arrhizus (species) [taxon 64495], Rhizopus microsporus (species) [taxon 58291], Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12014429/full.md

---
Source: https://tomesphere.com/paper/PMC12014429