# Simultaneous Transcatheter Pulmonary and Tricuspid Valve Replacement in Carcinoid Heart Disease

**Authors:** Varius Dannenberg, Caglayan Demirel, Markus Raderer, Barbara Kiesewetter, Lukas Reider, Anna Bartunek, Martin Andreas, Daniel Zimpfer, Jutta Bergler-Klein, Christian Hengstenberg, Philipp E. Bartko

PMC · DOI: 10.1016/j.jaccas.2025.103546 · 2025-03-26

## TL;DR

This paper describes a successful case of replacing two heart valves in a patient with carcinoid heart disease using a less invasive method.

## Contribution

The paper demonstrates the feasibility of simultaneous transcatheter valve replacement in carcinoid heart disease.

## Key findings

- Simultaneous transcatheter pulmonary and tricuspid valve replacement was performed successfully.
- The procedure almost eliminated regurgitation and improved right heart failure symptoms.
- Transcatheter approaches offer an effective alternative for high-risk patients with carcinoid heart disease.

## Abstract

Neuroendocrine tumors can cause carcinoid heart disease, often presenting with pulmonary and tricuspid regurgitation. Valvular pathology and right heart failure can influence prognosis more than the tumor itself. Given high surgical risk, prolonged recovery, and limited life expectancy, interventional valve replacement is a strong alternative.

We present a patient with severe pulmonary and torrential tricuspid regurgitation caused by carcinoid heart disease. Despite stable neuroendocrine tumor control, the patient developed progressive right heart failure, requiring urgent valve therapy. Simultaneous transcatheter pulmonary and tricuspid valve replacements were performed, almost eliminating tricuspid and pulmonary regurgitation.

Right heart valve failure is frequent in carcinoid heart disease and significantly impacts outcomes. Although surgical valve replacement remains the standard, transcatheter approaches provide an effective, less invasive alternative for high-risk patients, offering symptom relief and excellent results.

Simultaneous interventional valve replacement in carcinoid heart disease is feasible and effective.

## Linked entities

- **Diseases:** carcinoid heart disease (MONDO:0043529)

## Full-text entities

- **Diseases:** tumor (MESH:D009369), Carcinoid Heart Disease (MESH:D002275), pulmonary and tricuspid regurgitation (MESH:D014262), Right heart valve failure (MESH:D006333), Neuroendocrine tumors (MESH:D018358)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12014326/full.md

---
Source: https://tomesphere.com/paper/PMC12014326