# Ninjin’yoeito improves respiratory symptoms after lung cancer surgery: a prospective randomized study

## TL;DR

Ninjin’yoeito, a traditional herbal medicine, helps reduce respiratory symptoms and malnutrition after lung cancer surgery.

## Contribution

This is the first prospective randomized study to show ninjin’yoeito's effectiveness in post-lung surgery recovery.

## Key findings

- Ninjin’yoeito improved respiratory symptoms more than conventional treatment.
- It also reduced malnutrition rates 16 weeks after surgery.
- Respiratory function, like vital capacity, improved more in the ninjin’yoeito group.

## Abstract

This study evaluated the efficacy of ninjin’yoeito for alleviating postoperative symptoms after lung cancer surgery.

Overall, 140 patients who underwent lobectomy were randomized into a conventional treatment group and a ninjin’yoeito group. The primary endpoint was change in the Cancer Fatigue Scale (CFS) score from baseline and the secondary endpoints were the Cancer Dyspnea Scale (CDS) scores, the Kihon Checklist, and respiratory function.

The mean change in the CFS score 8 weeks postoperatively was − 5.56 in the ninjin’yoeito group and − 5.53 in the conventional treatment group (P = 0.425), but this outcome did not meet the primary endpoint. Changes in the mean CDS scores 8 weeks postoperatively were − 5.60 and − 3.38 in the ninjin’yoeito and conventional groups, respectively, with a difference of − 1.95 (P = 0.049). The changes in the mean vital capacity 8 weeks postoperatively were − 340.5 mL in the ninjin’yoeito group and − 473.5 mL in the conventional treatment group, with a difference of + 135.1 mL (P = 0.041). The ninjin’yoeito group had a significantly lower proportion of patients with malnutrition 16 weeks postoperatively than the conventional treatment group (P = 0.040).

The results of this study show that ninjin’yoeito is effective for alleviating respiratory symptoms and improving malnutrition after lung cancer surgery.