# Rapidly Expanding Odontogenic Myxoma: An Entity With Diagnostic Challenges—A Case Report

**Authors:** Suwarna Dangore-Khasbage, Rajanikanth Kambala, Hanadi Sabban, Aakanksha Tiwari, Monika Khubchandani

PMC · DOI: 10.1155/crid/5741422 · Case Reports in Dentistry · 2025-04-14

## TL;DR

This case report describes a rare, rapidly growing odontogenic myxoma in a young woman, highlighting the challenges in diagnosing this benign tumor.

## Contribution

The novelty lies in presenting a case of odontogenic myxoma with aggressive, rapid expansion in an unusual location.

## Key findings

- The tumor rapidly expanded in the mandibular ramus and angle over a few months.
- Histopathological examination was necessary to confirm the diagnosis due to overlapping radiographic features with other lesions.
- The case emphasizes the importance of histopathology for accurate diagnosis despite initial radiographic findings.

## Abstract

Odontogenic myxoma is a rare benign odontogenic tumor having locally aggressive behavior. It frequently affects the females in the second or third decade of life and commonly occurs in the mandibular posterior region as a slow-growing lesion. The aggressive behavior is often seen in maxillary lesions. However, this case report describes odontogenic myxoma with aggressive or rapidly expanding behavior occupying the ramus and angle of the mandible in few months. An 18-year-old girl reported with a chief complaint of gradually increasing painless swelling in the posterior region of the mandible for 4 months. Extraoral examination revealed diffuse, firm to hard, nontender swelling on the left mandibular posterior region and intraorally missing mandibular left third molar with expansion in the buccal and lingual aspect in the mandibular posterior region. Radiographic features depicted large well-defined multilocular radiolucency and impacted mandibular left third molar. Based on clinical features and radiographic findings, ameloblastic fibroma, dentigerous cyst, unicystic ameloblastoma, and odontogenic keratocyst were the entities considered in differential diagnosis. However, the histopathological examination confirmed it as odontogenic myxoma which was then treated surgically. This concludes that though radiographic examination is the first step meant for diagnosis, odontogenic myxoma depicts variety of radiographic features mandating histopathological examination for confirmation of the diagnosis.

## Full-text entities

- **Diseases:** odontogenic keratocyst (MESH:D009807), dentigerous cyst (MESH:D003803), maxillary (MESH:D008439), swelling (MESH:D004487), Odontogenic Myxoma (MESH:D009232), unicystic ameloblastoma (MESH:D000564), odontogenic tumor (MESH:D009808), ameloblastic fibroma (MESH:D005350)

## Full text

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## Figures

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## References

35 references — full list in the complete paper: https://tomesphere.com/paper/PMC12011459/full.md

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Source: https://tomesphere.com/paper/PMC12011459