# An Unresectable Eyelid Squamous Cell Carcinoma Treated With Concurrent Chemoradiation Therapy

**Authors:** Kenzo Ohara, Yuto Izumiya, Takahiro Inoue, Takumi Kumai, Miki Takahara

PMC · DOI: 10.7759/cureus.80984 · Cureus · 2025-03-22

## TL;DR

This paper presents a treatment approach for advanced eyelid cancer that cannot be surgically removed, using chemotherapy and radiation therapy.

## Contribution

The paper introduces a feasible chemoradiation therapy for unresectable eyelid squamous cell carcinoma.

## Key findings

- A case of unresectable eyelid squamous cell carcinoma was treated with cisplatin and docetaxel chemotherapy combined with radiation.
- The treatment approach may be suitable for advanced skin squamous cell carcinoma patients who cannot undergo surgery.

## Abstract

Cases of advanced eyelid squamous cell carcinoma (ESCC) are rare because most patients with eyelid cancer visit hospitals when the cancer is in relatively early stages. However, utill date, no study has recommended the most suitable treatment method for unresectable advanced skin squamous cell carcinoma (SSCC). Herein, we report a case of unresectable ESCC that invaded the orbital contents and paranasal sinuses, and was treated with moderate-dose cisplatin and docetaxel chemotherapy with radiation therapy. Our treatment method may be a feasible option for patients with advanced SSCC.

## Linked entities

- **Chemicals:** cisplatin (PubChem CID 5460033), docetaxel (PubChem CID 148124)
- **Diseases:** skin squamous cell carcinoma (MONDO:0002529)

## Full-text entities

- **Diseases:** ESCC (MESH:D002294), cancer (MESH:D009369)
- **Chemicals:** cisplatin (MESH:D002945), docetaxel (MESH:D000077143)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12011349/full.md

## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12011349/full.md

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Source: https://tomesphere.com/paper/PMC12011349