# Immunoregulatory Enzymes

## TL;DR

This review explores enzymes that regulate immune responses and their roles in health and disease.

## Contribution

The paper provides a comprehensive analysis of key immunoregulatory enzymes and their medical applications.

## Key findings

- Immunoregulatory enzymes like IDO1 and arginase 1 influence immune responses and disease progression.
- Dysfunction of these enzymes can lead to suppressed antitumor or anti-infectious immunity.
- New medical applications for these enzymes are being explored.

## Abstract

Immunoregulatory enzymes, which function both as biological catalysts and
regulatory elements, play a crucial role in controlling immune responses.
Dysfunction of these proteins can contribute to various pathological
conditions, such as the suppression of antitumor immunity or impairment of
anti-infectious immune responses. This review discusses the most extensively
studied immunoregulatory enzymes, including indoleamine 2,3-dioxygenase 1,
arginase 1, inducible nitric oxide synthase, glyceraldehyde-3-phosphate
dehydrogenase, and ectonucleoside triphosphate diphosphohydrolase 1. Their
classification is provided, along with an analysis of the distinctive
characteristics inherent to this group of enzymes. Additionally, new directions
for the medical application of immunoregulatory enzymes are explored.