# Is galactomannan a useful tool for triage and diagnosis of oral invasive aspergillosis?

## TL;DR

This study assesses the effectiveness of the galactomannan serum test in diagnosing oral invasive aspergillosis in neutropenic patients.

## Contribution

The study evaluates the diagnostic accuracy of galactomannan testing in oral invasive aspergillosis without pulmonary involvement.

## Key findings

- The galactomannan test showed 69% sensitivity and 100% specificity for diagnosing invasive aspergillosis.
- Higher sensitivity was observed in patients with sinusitis compared to those with exclusive oral lesions.
- The test's optical density index was significantly higher in confirmed aspergillosis cases.

## Abstract

To evaluate the accuracy of the galactomannan serum test in diagnosing oral invasive aspergillosis.

This prospective observational study included oncohematological neutropenic patients with suspected invasive aspergillosis, but without signs of pulmonary involvement. These patients underwent nasofibroscopy, biopsy, galactomannan serum testing, and maxillofacial high-resolution computed tomography to diagnose invasive aspergillosis. Patients were divided into two groups: Group 1 consisted of those with proven invasive aspergillosis, while Group 2 included patients without proven invasive aspergillosis. Sensitivity, specificity, positive predictive value, and negative predictive value were calculated.

Thirteen patients were included in Group 1 and four in Group 2. The sensitivity, specificity, positive predictive and negative predictive values were 0.69, 1.0, 1.0 and 0.5, respectively. Sensitivity was higher in cases with Aspergillus sinusitis than in cases with exclusive oral lesions (0.77 versus 0.5, respectively). The galactomannan serum test optical density index was higher in Group 1 (2.4; range 0.2–3.5) than in Group 2 (0.2; range: 0.1–0.3; P-value = 0.007.

The galactomannan serum test is a valuable tool for screening invasive aspergillosis, especially in cases with nasal or sinus involvement, but biopsy is still the gold standard for diagnosis.