# Bone marrow toxicity associated with febantel administration in a dog: Case Report

**Authors:** Abbey Petronzio, David Carabetta, Audrey Koid

PMC · DOI: 10.3389/fvets.2025.1557657 · Frontiers in Veterinary Science · 2025-04-07

## TL;DR

A dog developed bone marrow suppression after taking febantel, which is linked to fenbendazole, a known cause of similar toxicity in dogs.

## Contribution

This is the first reported case of bone marrow toxicity in a dog suspected to be caused by febantel administration.

## Key findings

- A 6-year-old dog showed bone marrow suppression after febantel administration.
- The dog recovered fully after discontinuing febantel and no other toxins were identified.
- Febantel is metabolized to fenbendazole, which is known to cause bone marrow toxicity in canines.

## Abstract

The objective of this case report is to describe a case of bone marrow suppression suspected to be secondary to febantel administration in a dog.

A 6-year-old neutered male Labrador Retriever was presented for lethargy and fever 15 days after receiving oral febantel. Pancytopenia was noted, and bone marrow sampling was consistent with hypoplasia suspected to be due to the febantel administration as no other toxic insults were identified. The dog made a full recovery in approximately 2 weeks after stopping the febantel.

This is the first report of suspected bone marrow toxicity secondary to febantel administration. Febantel is metabolized to fenbendazole, which has been documented as causing bone marrow toxicity in canines.

## Linked entities

- **Chemicals:** febantel (PubChem CID 135449328), fenbendazole (PubChem CID 3334)

## Full-text entities

- **Diseases:** fever (MESH:D005334), lethargy (MESH:D053609), Bone marrow toxicity (MESH:D001855), Pancytopenia (MESH:D010198), hypoplasia (MESH:D000080344)
- **Chemicals:** fenbendazole (MESH:D005273), Febantel (MESH:C017309)
- **Species:** Canis lupus familiaris (dog, subspecies) [taxon 9615]

## Full text

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## Figures

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## References

25 references — full list in the complete paper: https://tomesphere.com/paper/PMC12010925/full.md

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Source: https://tomesphere.com/paper/PMC12010925