# Parenchymal neuro-sonological characteristics in epileptic patients and their correlation with cognitive dysfunction

## TL;DR

This study found that patients with idiopathic generalized epilepsy have cognitive impairments and enlarged brain ventricles, which may indicate brain atrophy.

## Contribution

The study identifies a correlation between cognitive dysfunction and ventricular dilation in idiopathic generalized epilepsy patients.

## Key findings

- IGE patients had significantly lower ACE-III scores in attention, memory, fluency, and total score compared to controls.
- Third and lateral ventricle diameters were significantly larger in IGE patients than in controls.
- No significant differences were found in language and visuospatial scores between IGE patients and controls.

## Abstract

Idiopathic generalized epilepsies (IGEs) are the most common syndromes within the “genetic generalized epilepsies” (GGEs). Patients with IGE often exhibit cognitive comorbidities. The primary objective of this study is to investigate the correlation between brain parenchymal sonography characteristics and cognitive impairment in IGE.

This study enrolled 26 patients with IGE and 26 age- and sex-matched controls. All participants underwent comprehensive evaluations including clinical examination, electroencephalography, magnetic resonance imaging epilepsy protocol, transcranial sonography (TCS) for third and lateral ventricular diameter measurements, and cognitive assessment using the Addenbrooke’s Cognitive Examination-III (ACE III).

This study found significantly lower scores in attention, memory, fluency, and total score of ACE-III in IGE patients compared to the control group (P-value = 0.011, 0.033, 0.007, and 0.001, respectively). However, no significant differences were observed between IGE patients and the control group in language and visuospatial score (P = 0.479 and 0.108, respectively). The average diameters of the third ventricle and lateral ventricle anterior horns were significantly larger in patients than in the control group (P-value 0.004, 0.009, and 0.012, respectively).

IGE patients exhibit significant cognitive impairment and notable dilatation of the third ventricle and lateral ventricles horns, which may serve as markers of brain atrophy.