# A Case of Systemic Lupus Erythematosus Complicated by Secondary Evans Syndrome

**Authors:** Madison Drallmeier, Meghan Grossmann, Alexis Haftka-George

PMC · DOI: 10.7759/cureus.80959 · Cureus · 2025-03-21

## TL;DR

This case report describes a young man with systemic lupus erythematosus complicated by secondary Evans syndrome, leading to severe health issues and death.

## Contribution

The paper presents a rare clinical case highlighting the challenges and outcomes of secondary Evans syndrome in a systemic lupus erythematosus patient.

## Key findings

- The patient had multiple relapses and complications including infections and bleeding events.
- Secondary Evans syndrome was associated with a poor prognosis in this systemic lupus erythematosus case.
- The patient ultimately passed away due to complications from the conditions.

## Abstract

Evans syndrome (ES) is a condition that describes the development of multiple cytopenias, including autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), and autoimmune neutropenia (AIN). ES can be idiopathic or caused by an underlying condition, known as secondary ES. While secondary ES is associated with increased morbidity and mortality, any diagnosis of ES confers a poor prognosis. In this case report, we describe a young male patient diagnosed with systemic lupus erythematosus (SLE) and secondary ES that was complicated by multiple relapses and subsequent infections, bleeding events, and thrombotic events that ultimately led to the passing of the patient.

## Linked entities

- **Diseases:** Systemic Lupus Erythematosus (MONDO:0007915), Evans syndrome (MONDO:0016030), autoimmune hemolytic anemia (MONDO:0020108), immune thrombocytopenia (MONDO:0002048)

## Full-text entities

- **Diseases:** AIN (MESH:D009503), infections (MESH:D007239), bleeding (MESH:D006470), ITP (MESH:D016553), SLE (MESH:D008180), thrombotic (MESH:D013927), ES (MESH:C536380), cytopenias (MESH:D006402), AIHA (MESH:D000744)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12009602/full.md

## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12009602/full.md

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Source: https://tomesphere.com/paper/PMC12009602